The interleukin-23/interleukin-17 Axis Links Adaptive and innate immunity in Psoriasis

DC FieldValueLanguage
dc.contributor.authorSchoen, Michael P.
dc.contributor.authorErpenbeck, Luise
dc.date.accessioned2021-12-23T16:09:16Z-
dc.date.available2021-12-23T16:09:16Z-
dc.date.issued2018
dc.identifier.issn16643224
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/8705-
dc.description.abstractResearch into the pathophysiology of psoriasis has shed light onto many fascinating immunological interactions and underlying genetic constellations. Most prominent among these is the crosstalk between components of the innate and the adaptive immune system and the crucial role of interleukins (IL)-23 and -17 within this network. While it is clear that IL-23 drives and maintains the differentiation of Th17 lymphocytes, many aspects of the regulation of IL-23 and IL-17 are not quite as straightforward and have been unraveled only recently. For example, we know now that Th17 cells are not the only source of IL-17 but that cells of the innate immune system also produce considerable amounts of this central effector cytokine. In addition, there is IL-23-independent production of IL-17. Besides other innate immune cells, neutrophilic granulocytes prominently contribute to IL-17-related immune regulations in psoriasis, and it appears that they employ several mechanisms including the formation of neutrophil extracellular traps. Here, we strive to put the central role of the IL-23/IL-17 axis into perspective within the crosstalk between components of the innate and the adaptive immune system. Our aim is to better understand the complex immune regulation in psoriasis, a disorder that has become a model disease for chronic inflammation.
dc.language.isoen
dc.publisherFRONTIERS MEDIA SA
dc.relation.ispartofFRONTIERS IN IMMUNOLOGY
dc.subject6-SULFO LACNAC
dc.subjectadaptive immunity
dc.subjectCHROMATIN DECONDENSATION
dc.subjectCIRCULATING T-CELLS
dc.subjectDOWN-REGULATION
dc.subjectHUMAN KERATINOCYTES
dc.subjectIL-23/TH17 AXIS
dc.subjectImmunology
dc.subjectinnate immunity
dc.subjectinterleukin-17
dc.subjectinterleukin-23
dc.subjectNEUTROPHIL EXTRACELLULAR TRAPS
dc.subjectPLAQUE PSORIASIS
dc.subjectPLASMACYTOID DENDRITIC CELLS
dc.subjectpsoriasis
dc.subjectPUSTULAR PSORIASIS
dc.titleThe interleukin-23/interleukin-17 Axis Links Adaptive and innate immunity in Psoriasis
dc.typereview
dc.identifier.doi10.3389/fimmu.2018.01323
dc.identifier.isiISI:000435380700001
dc.description.volume9
dc.contributor.orcid0000-0002-6561-472X
dc.publisher.placeAVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
dcterms.isPartOf.abbreviationFront. Immunol.
dcterms.oaStatusGreen Published, gold
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