Phylogenomic analysis of type 1 NADH:Quinone oxidoreductase

DC FieldValueLanguage
dc.contributor.authorNovakovsky, G. E.
dc.contributor.authorDibrova, D. V.
dc.contributor.authorMulkidjanian, A. Y.
dc.date.accessioned2021-12-23T16:09:36Z-
dc.date.available2021-12-23T16:09:36Z-
dc.date.issued2016
dc.identifier.issn00062979
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/8889-
dc.description.abstractWe performed phylogenomic analysis of the catalytic core of NADH:quinone oxidoreductases of type 1 (NDH-1). Analysis of phylogenetic trees, as constructed for the core subunits of NDH-1, revealed fundamental differences in their topologies. In the case of four putatively homologous ion-carrying membrane subunits, the trees for the NuoH and NuoN subunits contained separate archaeal clades, whereas subunits NuoL and NuoM were characterized by multiple archaeal clades spread among bacterial branches. Large, separate clades, which united sequences belonging to different archaeal subdomains, were also found for cytoplasmic subunits NuoD and NuoB, homologous to the large and small subunits of nickel-iron hydrogenases. A smaller such clade was also shown for subunit NuoC. Based on these data, we suggest that the ancestral NDH-1 complex could be present already at the stage of the Last Universal Cellular Ancestor (LUCA). Ancestral forms of membrane subunits NuoN and NuoH and cytoplasmic subunits NuoD, NuoB, and, perhaps NuoC, may have formed a membrane complex that operated as an ion-translocating membrane hydrogenase. After the complex attained the ability to reduce membrane quinones, gene duplications could yield the subunits NuoL and NuoM, which enabled translocation of additional ions.
dc.description.sponsorshipRussian Science FoundationRussian Science Foundation (RSF) [14-50-00029, 14-14-00592]; This work was supported by the Russian Science Foundation (projects No. 14-50-00029, G. E. Novakovsky, phylogenomic analysis of separate subunits of NDH-1; No. 14-14-00592, D. V. Dibrova and A. Y. Mulkidjanian, construction of the evolution scheme for the whole enzyme and its modules).
dc.language.isoen
dc.publisherMAIK NAUKA/INTERPERIODICA/SPRINGER
dc.relation.ispartofBIOCHEMISTRY-MOSCOW
dc.subjectARCHAEA
dc.subjectBiochemistry & Molecular Biology
dc.subjectENERGY
dc.subjectEVOLUTION
dc.subjectF-TYPE
dc.subjectMULTIPLE SEQUENCE ALIGNMENT
dc.subjectNADH
dc.subjectNIFE HYDROGENASES
dc.subjectORIGIN
dc.subjectRESPIRATORY COMPLEX-I
dc.subjectSTOICHIOMETRY
dc.titlePhylogenomic analysis of type 1 NADH:Quinone oxidoreductase
dc.typejournal article
dc.identifier.doi10.1134/S0006297916070142
dc.identifier.isiISI:000379852700014
dc.description.volume81
dc.description.issue7
dc.description.startpage770
dc.description.endpage784
dc.contributor.orcid0000-0001-5844-3064
dc.contributor.orcid0000-0002-6954-6437
dc.contributor.researcheridAAH-3608-2021
dc.contributor.researcheridJ-8086-2013
dc.contributor.researcheridC-6003-2014
dc.identifier.eissn16083040
dc.publisher.place233 SPRING ST, NEW YORK, NY 10013-1578 USA
dcterms.isPartOf.abbreviationBiochem.-Moscow
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