The role of transmembrane domains in membrane fusion

DC FieldValueLanguage
dc.contributor.authorLangosch, D.
dc.contributor.authorHofmann, M.
dc.contributor.authorUngermann, C.
dc.date.accessioned2021-12-23T16:09:39Z-
dc.date.available2021-12-23T16:09:39Z-
dc.date.issued2007
dc.identifier.issn1420682X
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/8911-
dc.description.abstractBiological membrane fusion is driven by different types of molecular fusion machines. Most of these proteins are membrane-anchored by single transmembrane domains. SNARE proteins are essential for intracellular membrane fusion along the secretory and endocytic pathway, while various viral fusogens mediate infection of eukaryotic cells by enveloped viruses. Although both types of fusion proteins are evolutionarily quite distant from each other, they do share a number of structural and functional features. Their transmembrane domains are now known to be critical for the fusion reaction. We discuss at which stages they might contribute to bilayer mixing.
dc.language.isoen
dc.publisherSPRINGER BASEL AG
dc.relation.ispartofCELLULAR AND MOLECULAR LIFE SCIENCES
dc.subjectBiochemistry & Molecular Biology
dc.subjectCell Biology
dc.subjectCONFORMATIONAL-CHANGE
dc.subjectCONSERVED GLYCINE RESIDUES
dc.subjectfusion pore
dc.subjecthemifusion
dc.subjectHEMIFUSION INTERMEDIATE
dc.subjectIMMUNODEFICIENCY-VIRUS TYPE-1
dc.subjectmembrane fusion
dc.subjectPROTEIN INTERACTIONS
dc.subjectSECONDARY STRUCTURE
dc.subjectSNARE
dc.subjectSNARE COMPLEX
dc.subjectSPANNING DOMAIN
dc.subjecttransmembrane domain
dc.subjectVACUOLE FUSION
dc.subjectVIRAL FUSION
dc.titleThe role of transmembrane domains in membrane fusion
dc.typereview
dc.identifier.doi10.1007/s00018-007-6439-x
dc.identifier.isiISI:000245669400006
dc.description.volume64
dc.description.issue7-8
dc.description.startpage850
dc.description.endpage864
dc.identifier.eissn14209071
dc.publisher.placePICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
dcterms.isPartOf.abbreviationCell. Mol. Life Sci.
crisitem.author.netidUnCh999-
Show simple item record

Google ScholarTM

Check

Altmetric