Inner workings and biological impact of phospholipid flippases

Autor(en): Panatala, Radhakrishnan
Hennrich, Hanka
Holthuis, Joost C. M.
Stichwörter: Cell Biology; ENDOPLASMIC-RETICULUM; FAMILIAL INTRAHEPATIC CHOLESTASIS; Flippase; Golgi complex; HUMAN-ERYTHROCYTE-GHOSTS; LIPID ASYMMETRY; P-TYPE ATPASE; Phosphatidylserine; PROTEIN-TRANSPORT; PUTATIVE AMINOPHOSPHOLIPID TRANSLOCASES; SACCHAROMYCES-CEREVISIAE; TRANS-GOLGI NETWORK; Vesicular transport; YEAST PLASMA-MEMBRANE
Erscheinungsdatum: 2015
Herausgeber: COMPANY OF BIOLOGISTS LTD
Journal: JOURNAL OF CELL SCIENCE
Volumen: 128
Ausgabe: 11
Startseite: 2021
Seitenende: 2032
Zusammenfassung: 
The plasma membrane, trans-Golgi network and endosomal system of eukaryotic cells are populated with flippases that hydrolyze ATP to help establish asymmetric phospholipid distributions across the bilayer. Upholding phospholipid asymmetry is vital to a host of cellular processes, including membrane homeostasis, vesicle biogenesis, cell signaling, morphogenesis and migration. Consequently, defining the identity of flippases and their biological impact has been the subject of intense investigations. Recent work has revealed a remarkable degree of kinship between flippases and cation pumps. In this Commentary, we review emerging insights into how flippases work, how their activity is controlled according to cellular demands, and how disrupting flippase activity causes system failure of membrane function, culminating in membrane trafficking defects, aberrant signaling and disease.
ISSN: 00219533
DOI: 10.1242/jcs.102715

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