Immune response of the ant Camponotus floridanus against pathogens and its obligate mutualistic endosymbiont

Autor(en): Ratzka, Carolin
Liang, Chunguang
Dandekar, Thomas
Gross, Roy
Feldhaar, Heike
Stichwörter: ACTIVATION; BACTERIOCYTE; Biochemistry & Molecular Biology; Blochmannia floridanus; BLOCHMANNIA-FLORIDANUS; Camponotus floridanus; Carpenter ants; DROSOPHILA; Endosymbiosis; Entomology; Gene expression regulation; GENE-EXPRESSION; GENOME; HOST-DEFENSE; IDENTIFICATION; Innate immunity; INSECT; PEPTIDE GENES
Erscheinungsdatum: 2011
Herausgeber: PERGAMON-ELSEVIER SCIENCE LTD
Journal: INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volumen: 41
Ausgabe: 8
Startseite: 529
Seitenende: 536
Zusammenfassung: 
Numerous insect species harbor mutualistic endosymbionts that play a role in nutrient cycling or confer other fitness benefits to their hosts. Insect hosts face the problem of having to maintain such mutualistic bacteria while staging an immune response towards pathogens upon infection. In addition, hosts may regulate the number of endosymbionts present in their tissues via the innate immune system. Camponotus floridanus ants harbor the obligate endosymbiont Blochmannia floridanus in specialized midgut cells and ovaries. We identified genes transcriptionally induced in response to septic injury by suppression subtractive hybridization (SSH). Among these were genes involved in pathogen recognition (e.g. GNBP), signal transduction (e.g. MAPK-kinase), antimicrobial activity (e.g. defensin and hymenoptaecin), or general stress response (e.g. heat shock protein). A quantitative analysis of immune-gene expression revealed different expression kinetics of individual factors and also characteristic expression profiles after injection of gram-negative and gram-positive bacteria. Likewise, B. floridanus injected into the hemocoel elicited a comparable immune response of its host C. floridanus. Thus, the host immune system may contribute to controlling the endosymbiont population. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN: 09651748
DOI: 10.1016/j.ibmb.2011.03.002

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