Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer

DC FieldValueLanguage
dc.contributor.authorSrivastava, P.
dc.contributor.authorEl Asrar, R. Abou
dc.contributor.authorKnies, C.
dc.contributor.authorAbramov, M.
dc.contributor.authorFroeyen, M.
dc.contributor.authorRozenski, J.
dc.contributor.authorRosemeyer, H.
dc.contributor.authorHerdewijn, P.
dc.date.accessioned2021-12-23T16:10:49Z-
dc.date.available2021-12-23T16:10:49Z-
dc.date.issued2015
dc.identifier.issn14770520
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/9406-
dc.description.abstractThe search for prebiotic, nucleic acid precursors is, at its best, a speculative undertaking. Given the complex structure of RNA, it is not very likely that RNA was the first information system in the universe and thus finding possible precursor/s i.e. pre-RNA remains an open challenge. We, in this paper, have tried to construct nucleic acid polymers with a simple acyclic, achiral backbone. Such a linear, achiral backbone may have been formed from simple monomers that may have existed in the ``prebiotic soup''. We have shown that such polymers are capable of identifying the complementary ``other self'' and thus forming a potential system for information storage and transmission. This study thus involves investigation of nucleic acid analogues with a modified backbone that are likely to have formed in the prebiotic setting.
dc.description.sponsorshipHercules Foundation of the Flemish Government [20100225-7]; FWO (Vlaanderen)FWO [G.078014N]; European Research Council under European Union's Seventh Framework Programme [ERC-2012-ADG_20120216/320683]; Mass spectrometry was made possible with the support of the Hercules Foundation of the Flemish Government (grant 20100225-7). We thank FWO (Vlaanderen) (G.078014N) for financial support. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement no ERC-2012-ADG_20120216/320683. We thank Guy Schepers for synthesis and purification of oligonucleotides and T<INF>m</INF> measurement and Chantal Biernaux for editorial support.
dc.language.isoen
dc.publisherROYAL SOC CHEMISTRY
dc.relation.ispartofORGANIC & BIOMOLECULAR CHEMISTRY
dc.subjectANALOGS
dc.subjectB-DNA DODECAMER
dc.subjectChemistry
dc.subjectChemistry, Organic
dc.subjectCRYSTAL-STRUCTURE
dc.subjectGLYCEROL-NUCLEOSIDE TRIPHOSPHATES
dc.subjectLIFE
dc.subjectORIGIN
dc.subjectPNA
dc.subjectRNA
dc.subjectSTABLE DUPLEX FORMATION
dc.titleAchiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer
dc.typejournal article
dc.identifier.doi10.1039/c5ob00898k
dc.identifier.isiISI:000360115100013
dc.description.volume13
dc.description.issue35
dc.description.startpage9249
dc.description.endpage9260
dc.contributor.orcid0000-0002-8675-6540
dc.contributor.orcid0000-0001-9624-5536
dc.contributor.orcid0000-0001-9947-2697
dc.contributor.orcid0000-0003-3589-8503
dc.contributor.researcheridI-1665-2014
dc.identifier.eissn14770539
dc.publisher.placeTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
dcterms.isPartOf.abbreviationOrg. Biomol. Chem.
dcterms.oaStatusGreen Accepted
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidRoHe783-
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