Up against the Wall: Is Yeast Cell Wall Integrity Ensured by Mechanosensing in Plasma Membrane Microdomains?

DC FieldValueLanguage
dc.contributor.authorKock, Christian
dc.contributor.authorDufrene, Yves F.
dc.contributor.authorHeinisch, Juergen J.
dc.date.accessioned2021-12-23T16:11:13Z-
dc.date.available2021-12-23T16:11:13Z-
dc.date.issued2015
dc.identifier.issn00992240
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/9587-
dc.description.abstractYeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of antifungal drugs. A set of five membrane-spanning sensors (Wsc1 to Wsc3, Mid2, and Mtl1) detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. We here summarize the latest advances in the structure/function relationship primarily of the Wsc1 sensor and critically review the evidence that it acts as a mechanosensor. The relevance and physiological significance of the information obtained for the function of the other CWI sensors, as well as expected future developments, are discussed.
dc.description.sponsorshipNational Foundation for Scientific Research (FNRS)Fonds de la Recherche Scientifique - FNRS; Universite Catholique de Louvain (Fonds Speciaux de Recherche); Federal Office for Scientific, Technical and Cultural Affairs (Interuniversity Poles of Attraction Programme); Research Department of the Communaute Francaise de Belgique (Concerted Research Action); Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SFB944]; Work at the Universite Catholique de Louvain was supported by the National Foundation for Scientific Research (FNRS), the Universite Catholique de Louvain (Fonds Speciaux de Recherche), the Federal Office for Scientific, Technical and Cultural Affairs (Interuniversity Poles of Attraction Programme), and the Research Department of the Communaute Francaise de Belgique (Concerted Research Action). Y.F.D. is a Research Director at the FNRS. Work in the laboratory of J.J.H. was supported by a grant from the Deutsche Forschungsgemeinschaft within the framework of SFB944.
dc.language.isoen
dc.publisherAMER SOC MICROBIOLOGY
dc.relation.ispartofAPPLIED AND ENVIRONMENTAL MICROBIOLOGY
dc.subjectANTIFUNGAL AGENTS
dc.subjectATOMIC-FORCE MICROSCOPY
dc.subjectBAKERS-YEAST
dc.subjectBiotechnology & Applied Microbiology
dc.subjectKLUYVEROMYCES-LACTIS
dc.subjectMicrobiology
dc.subjectO-MANNOSYLATION
dc.subjectPROTEIN-KINASE-C
dc.subjectSACCHAROMYCES-CEREVISIAE
dc.subjectSENSOR
dc.subjectSTRESS-RESPONSE
dc.subjectWSC1
dc.titleUp against the Wall: Is Yeast Cell Wall Integrity Ensured by Mechanosensing in Plasma Membrane Microdomains?
dc.typereview
dc.identifier.doi10.1128/AEM.03273-14
dc.identifier.isiISI:000347914800001
dc.description.volume81
dc.description.issue3
dc.description.startpage806
dc.description.endpage811
dc.contributor.orcid0000-0002-7289-4248
dc.contributor.researcheridG-3801-2017
dc.identifier.eissn10985336
dc.publisher.place1752 N ST NW, WASHINGTON, DC 20036-2904 USA
dcterms.isPartOf.abbreviationAppl. Environ. Microbiol.
dcterms.oaStatusGreen Published, Bronze
crisitem.author.deptSonderforschungsbereich 944: Physiologie und Dynamik zellulärer Mikrokompartimente-
crisitem.author.deptidorganisation19-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidKoCh062-
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