Up against the Wall: Is Yeast Cell Wall Integrity Ensured by Mechanosensing in Plasma Membrane Microdomains?
DC Element | Wert | Sprache |
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dc.contributor.author | Kock, Christian | |
dc.contributor.author | Dufrene, Yves F. | |
dc.contributor.author | Heinisch, Juergen J. | |
dc.date.accessioned | 2021-12-23T16:11:13Z | - |
dc.date.available | 2021-12-23T16:11:13Z | - |
dc.date.issued | 2015 | |
dc.identifier.issn | 00992240 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/9587 | - |
dc.description.abstract | Yeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of antifungal drugs. A set of five membrane-spanning sensors (Wsc1 to Wsc3, Mid2, and Mtl1) detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. We here summarize the latest advances in the structure/function relationship primarily of the Wsc1 sensor and critically review the evidence that it acts as a mechanosensor. The relevance and physiological significance of the information obtained for the function of the other CWI sensors, as well as expected future developments, are discussed. | |
dc.description.sponsorship | National Foundation for Scientific Research (FNRS)Fonds de la Recherche Scientifique - FNRS; Universite Catholique de Louvain (Fonds Speciaux de Recherche); Federal Office for Scientific, Technical and Cultural Affairs (Interuniversity Poles of Attraction Programme); Research Department of the Communaute Francaise de Belgique (Concerted Research Action); Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SFB944]; Work at the Universite Catholique de Louvain was supported by the National Foundation for Scientific Research (FNRS), the Universite Catholique de Louvain (Fonds Speciaux de Recherche), the Federal Office for Scientific, Technical and Cultural Affairs (Interuniversity Poles of Attraction Programme), and the Research Department of the Communaute Francaise de Belgique (Concerted Research Action). Y.F.D. is a Research Director at the FNRS. Work in the laboratory of J.J.H. was supported by a grant from the Deutsche Forschungsgemeinschaft within the framework of SFB944. | |
dc.language.iso | en | |
dc.publisher | AMER SOC MICROBIOLOGY | |
dc.relation.ispartof | APPLIED AND ENVIRONMENTAL MICROBIOLOGY | |
dc.subject | ANTIFUNGAL AGENTS | |
dc.subject | ATOMIC-FORCE MICROSCOPY | |
dc.subject | BAKERS-YEAST | |
dc.subject | Biotechnology & Applied Microbiology | |
dc.subject | KLUYVEROMYCES-LACTIS | |
dc.subject | Microbiology | |
dc.subject | O-MANNOSYLATION | |
dc.subject | PROTEIN-KINASE-C | |
dc.subject | SACCHAROMYCES-CEREVISIAE | |
dc.subject | SENSOR | |
dc.subject | STRESS-RESPONSE | |
dc.subject | WSC1 | |
dc.title | Up against the Wall: Is Yeast Cell Wall Integrity Ensured by Mechanosensing in Plasma Membrane Microdomains? | |
dc.type | review | |
dc.identifier.doi | 10.1128/AEM.03273-14 | |
dc.identifier.isi | ISI:000347914800001 | |
dc.description.volume | 81 | |
dc.description.issue | 3 | |
dc.description.startpage | 806 | |
dc.description.endpage | 811 | |
dc.contributor.orcid | 0000-0002-7289-4248 | |
dc.contributor.researcherid | G-3801-2017 | |
dc.identifier.eissn | 10985336 | |
dc.publisher.place | 1752 N ST NW, WASHINGTON, DC 20036-2904 USA | |
dcterms.isPartOf.abbreviation | Appl. Environ. Microbiol. | |
dcterms.oaStatus | Green Published, Bronze | |
crisitem.author.dept | Sonderforschungsbereich 944: Physiologie und Dynamik zellulärer Mikrokompartimente | - |
crisitem.author.deptid | organisation19 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | KoCh062 | - |
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geprüft am 28.05.2024