Site-specific pK(a) determination of the carboxylate-binding subunit in artificial peptide receptors

Autor(en): Niebling, Stephan
Srivastava, Sunil K.
Herrmann, Christoph
Wich, Peter R.
Schmuck, Carsten
Schluecker, Sebastian
Stichwörter: AQUEOUS-SOLUTION; Chemistry; Chemistry, Multidisciplinary; RECOGNITION; TETRAPEPTIDES; WATER
Erscheinungsdatum: 2010
Herausgeber: ROYAL SOC CHEMISTRY
Journal: CHEMICAL COMMUNICATIONS
Volumen: 46
Ausgabe: 12
Startseite: 2133
Seitenende: 2135
Zusammenfassung: 
Site-specific pK(a) determination of the carboxylate-binding subunit in artificial peptide receptors is achieved by pH-dependent UV resonance Raman scattering with subsequent matrix factorization. This quantitative methodology allows to determine accurately the local acidity of a binding site based on the complete vibrational spectrum and, most importantly, without the need of selecting any particular peak.
ISSN: 13597345
DOI: 10.1039/b926514g

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