Protein recycling is a major component of post-irradiation recovery in Deinococcus radiodurans strain R1

Autor(en): Joshi, B
Schmid, R
Altendorf, K 
Apte, SK
Stichwörter: Biochemistry & Molecular Biology; Biophysics; chaperones; Deinococcus; DEPLETION; EXPRESSION; EXTREME RADIORESISTANCE; GENOME; IONIZING-RADIATION; PHX proteins; post-irradiation recovery; protein recycling; proteomics; radioresistance; TARGETED MUTAGENESIS
Erscheinungsdatum: 2004
Herausgeber: ACADEMIC PRESS INC ELSEVIER SCIENCE
Journal: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volumen: 320
Ausgabe: 4
Startseite: 1112
Seitenende: 1117
Zusammenfassung: 
Exposure to 6 kGy dose of Co-60 gamma-rays resulted in immediate growth arrest, followed by complete recovery of Deinococcus radiodurans strain R1 cells. Selective degradation and resynthesis of several predicted highly expressed proteins (including major chaperones, key TCA cycle enzymes, and few stress proteins) and several hypothetical proteins marked the lag period, preceding resumption of growth. A major exercise in protein recycling appears to be an integral component of post-irradiation recovery in D. radiodurans and complements the extensive DNA repair, characteristic of this extremely radioresistant bacterium. (C) 2004 Elsevier Inc. All rights reserved.
ISSN: 0006291X
DOI: 10.1016/j.bbrc.2004.06.062

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