FGFR2 signaling and the pathogenesis of acne

Autor(en): Melnik, Bodo
Schmitz, Gerd
Stichwörter: 5-ALPHA-REDUCTASE; ABNORMALITIES; acne vulgaris; ANDROGEN RECEPTOR; Apert syndrome; Dermatology; EXPRESSION; FGF-FGFR2-signaling; GENE; interleukin-1 alpha; KERATINOCYTE GROWTH-FACTOR; LIGAND-BINDING SPECIFICITY; MUTATION; NEVUS; nevus comedonicus; sonic hedgehog; SONIC-HEDGEHOG; unilateral acneiform nevus
Erscheinungsdatum: 2008
Herausgeber: WILEY
Volumen: 6
Ausgabe: 9
Startseite: 721
Seitenende: 728
Acne in Apert syndrome and unilateral segmental acneiform nevus are associated with mutations of fibroblast growth factor receptor 2 (FGFR2), which are likely to be involved in the pathogenesis of acne. Translational animal and cellular models, developmental biology studies and clinical observations have contributed to our understanding of FGF-FGFR2 signaling in the pilosebaceous follicle. The importance of FGF-FGFR2 signaling in mesenchymal-epithelial interaction for skin appendage formation, pilosebaceous follicle homeostasis, comeclogenesis and sebaceous gland proliferation is explored. Overstimulation of FGFR2 signaling with increased expression of interleukin-1 alpha explains acne in Apert syndrome und nevus comedonicus. Androgen-mediated up-regulation of FGFR2 signaling could be the initiating signal in the pathogenesis of acne. The gain of function FGFR2 mutations in Apert syndrome and unilateral acneiform nevus are most helpful model diseases for uncovering the fundamental process of androgen-dependent mesenchymal-epithelial FGF-FGFR2 signaling in acne in Apert syndrome, nevus comedonicus and acne vulgaris.
ISSN: 16100379
DOI: 10.1111/j.1610-0387.2008.06822.x

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