Browsing by Author Garcia, K. Christopher


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Issue DateTitleAuthor(s)
2021Author response: Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonistGlassman, Caleb R.; Su, Leon; Majri-Morrison, Sonia S; Winkelmann, Hauke; Mo, Fei; Li, Peng; Pérez-Cruz, Magdiel; Ho, Peggy P.; Koliesnik, Ievgen O.; Nagy, Nadine; Hnizdilova, Tereza; Picton, Lora; Kovar, Marek; Bollyky, Paul L.; Steinman, Lawrence; Meyer, Everett; Piehler, Jacob ; Leonard, Warren J.; Garcia, K. Christopher
2022Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt SignalodropletsPhilippi, Michael; Richter, Christian P.; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspoetter, Michael; Kurre, Rainer ; Holthuis, Joost C. M.; Garcia, K. Christopher; Plueckthun, Andreas; Steinhart, Martin ; Piehler, Jacob ; You, Changjiang 
2022Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co‐Condensation of Wnt Signalodroplets (Small 50/2022)Philippi, Michael; Richter, Christian P.; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspötter, Michael; Kurre, Rainer ; Holthuis, Joost C. M.; Garcia, K. Christopher; Plückthun, Andreas; Steinhart, Martin ; Piehler, Jacob ; You, Changjiang 
2021Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonistGlassman, Caleb R.; Su, Leon; Majri-Morrison, Sonia S.; Winkelmann, Hauke; Mo, Fei; Li, Peng; Perez-Cruz, Magdiel; Ho, Peggy P.; Koliesnik, Ievgen; Nagy, Nadine; Hnizdilova, Tereza; Picton, Lora K.; Kovar, Marek; Bollyky, Paul; Steinman, Lawrence; Meyer, Everett; Piehler, Jacob ; Leonard, Warren J.; Garcia, K. Christopher
2017Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit SignalingHo, Chia Chi M.; Chhabra, Akanksha; Starkl, Philipp; Schnorr, Peter-John; Wilmes, Stephan; Moraga, Ignacio; Kwon, Hye-Sook; Gaudenzio, Nicolas; Sibilano, Riccardo; Wehrman, Tom S.; Gakovic, Milica; Sockolosky, Jonathan T.; Tiffany, Matthew R.; Ring, Aaron M.; Piehler, Jacob ; Weissman, Irving L.; Galli, Stephen J.; Shizuru, Judith A.; Garcia, K. Christopher
2023Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapyYang, Xinbo; Nishimiya, Daisuke; Löchte, Sara; Jude, Kevin M; Borowska, Marta; Savvides, Christina S; Dougan, Michael; Su, Leon; Zhao, Xiang; Piehler, Jacob ; Garcia, K. Christopher
2017Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO MutationKim, Ah Ram; Ulirsch, Jacob C.; Wilmes, Stephan; Unal, Ekrem; Moraga, Ignacio; Karakukcu, Musa; Yuan, Daniel; Kazerounian, Shideh; Abdulhay, Nour J.; King, David S.; Gupta, Namrata; Gabriel, Stacey B.; Lander, Eric S.; Patiroglu, Turkan; Ozcan, Alper; Ozdemir, Mehmet Akif; Garcia, K. Christopher; Piehler, Jacob ; Gazda, Hanna T.; Klein, Daryl E.; Sankaran, Vijay G.
2015Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potencyMoraga, Ignacio; Richter, David; Wilmes, Stephan; Winkelmann, Hauke; Jude, Kevin; Thomas, Christoph; Suhoski, Megan M.; Engleman, Edgar G.; Piehler, Jacob ; Garcia, K. Christopher
2017Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartmentsRichter, David; Moraga, Ignacio; Winkelmann, Hauke; Birkholz, Oliver; Wilmes, Stephan; Schulte, Markos; Kraich, Michael; Kenneweg, Hella; Beutel, Oliver; Selenschik, Philipp; Paterok, Dirk; Gavutis, Martynas; Schmidt, Thomas; Garcia, K. Christopher; Mueller, Thomas D.; Piehler, Jacob 
2022Live cell nanodot arrays uncover synergistic co-condensation of Wnt signalodropletsPhilippi, Michael; Richter, Christian; Kappen, Marie; Watrinet, Isabelle; Miao, Yi; Runge, Mercedes; Jorde, Lara; Korneev, Sergej; Holtmannspoetter, Michael; Kurre, Rainer ; Holthuis, Joost C. M.; Garcia, K. Christopher; Plueckthun, Andreas; Steinhart, Martin ; Piehler, Jacob ; You, Changjiang 
2020Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutationsWilmes, Stephan; Hafer, Maximillian; Vuorio, Joni; Tucker, Julie A.; Winkelmann, Hauke; Loechte, Sara; Stanly, Tess A.; Prieto, Katiuska D. Pulgar; Poojari, Chetan; Sharma, Vivek; Richter, Christian P.; Kurre, Rainer ; Hubbard, Stevan R.; Garcia, K. Christopher; Moraga, Ignacio; Vattulainen, Ilpo; Hitchcock, Ian S.; Piehler, Jacob 
2019New Paradigms for the Mechanisms of Thrombopoietin Receptor Activation and Dysregulation By the JAK2(V617F) MutationWilmes, Stephan; Hafer, Maximillian; Stanly, Tess A.; Moraga, Ignacio; Vuorio, Joni; Poojari, Chetan; Sharma, Vivek; Lochte, Sara; Prieto, Katiuska Pulgar; Tucker, Julie A.; Hubbard, Stevan R.; Garcia, K. Christopher; Vattulainen, Ilpo; Hitchcock, Ian; Piehler, Jacob 
2020Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In VivoMiao, Yi; Ha, Andrew; de Lau, Wim; Yuki, Kanako; Santos, Antonio J. M.; You, Changjiang ; Geurts, Maarten H.; Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Peng, Weng Chuan; Senlice, Ramazan; Piani, Carol; Buikema, Jan W.; Gbenedio, Oghenekevwe M.; Vallon, Mario; Yuan, Jenny; de Haan, Sanne; Hemrika, Wieger; Rosch, Kathrin; Dang, Luke T.; Baker, David; Ott, Melanie; Depeille, Philippe; Wu, Sean M.; Drost, Jarno; Nusse, Roeland; Roose, Jeroen P.; Piehler, Jacob ; Boj, Sylvia F.; Janda, Claudia Y.; Clevers, Hans; Kuo, Calvin J.; Garcia, K. Christopher
2022Organizing structural principles of the IL-17 ligand-receptor axisWilson, Steven C.; Caveney, Nathanael A.; Yen, Michelle; Pollmann, Christoph; Xiang, Xinyu; Jude, Kevin M.; Hafer, Maximillian; Tsutsumi, Naotaka; Piehler, Jacob ; Garcia, K. Christopher
2016Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signalingYou, Changjiang ; Marquez-Lago, Tatiana T.; Richter, Christian Paolo; Wilmes, Stephan; Moraga, Ignacio; Garcia, K. Christopher; Leier, Andre; Piehler, Jacob 
2012Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretationPiehler, Jacob ; Thomas, Christoph; Garcia, K. Christopher; Schreiber, Gideon
2011Structural Linkage between Ligand Discrimination and Receptor Activation by Type I InterferonsThomas, Christoph; Moraga, Ignacio; Levin, Doron; Krutzik, Peter O.; Podoplelova, Yulia; Trejo, Angelica; Lee, Choongho; Yarden, Ganit; Vleck, Susan E.; Glenn, Jeffrey S.; Nolan, Garry P.; Piehler, Jacob ; Schreiber, Gideon; Garcia, K. Christopher
2019Structure of the IFN gamma receptor complex guides design of biased agonistsMendoza, Juan L.; Escalante, Nichole K.; Jude, Kevin M.; Bellon, Junel Sotolongo; Su, Leon; Horton, Tim M.; Tsutsumi, Naotaka; Berardinelli, Steven J.; Haltiwanger, Robert S.; Piehler, Jacob ; Engleman, Edgar G.; Garcia, K. Christopher
2023Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesisTsutsumi, Naotaka; Masoumi, Zahra; James, Sophie C.; Tucker, Julie A.; Winkelmann, Hauke; Grey, William; Picton, Lora K.; Moss, Lucie; Wilson, Steven C.; Caveney, Nathanael A.; Jude, Kevin M.; Gati, Cornelius; Piehler, Jacob ; Hitchcock, Ian S.; Garcia, K. Christopher
2017Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signallingJanda, Claudia Y.; Dang, Luke T.; You, Changjiang ; Chang, Junlei; de Lau, Wim; Zhong, Zhendong A.; Yan, Kelley S.; Marecic, Owen; Siepe, Dirk; Li, Xingnan; Moody, James D.; Williams, Bart O.; Clevers, Hans; Piehler, Jacob ; Baker, David; Kuo, Calvin J.; Garcia, K. Christopher