Ion-specific aggregation of gold-DNA nanoparticles using the dG quartet hairpin 5 `-d(G(4)T(4)G(4))

Autor(en): Seela, F
Jawalekar, AM
Chi, LF
Zhong, DY
Stichwörter: Biochemistry & Molecular Biology; Chemistry; Chemistry, Multidisciplinary; G-QUADRUPLEX; POLYNUCLEOTIDES; STABILITY
Erscheinungsdatum: 2005
Herausgeber: VERLAG HELVETICA CHIMICA ACTA AG
Journal: CHEMISTRY & BIODIVERSITY
Volumen: 2
Ausgabe: 1
Startseite: 84
Seitenende: 91
Zusammenfassung: 
Ion-selective self-assembly of An nanoparticles is described. The Oxytricha telomere DNA hairpin 5'-d(G(4)T(4)G(4)) immobilized on 13-nm Au nanoparticles forms a supramolecular assembly via dG-quartets, as determined by the color change and by scanning electron microscopy (SEM). The aggregation is ion-dependent and selective for Na+ ions. K+ is less efficient, while Li+ and Cs+ do not drive the aggregation. This work is the first effort to explore the use of secondary structures of DNA (quadruplexes) for producing self-assemblies of Au nanoparticles. It can be utilized to generate novel devices and materials, potentially useful for sensing and other applications in medicinal or engineering science.
ISSN: 16121872
DOI: 10.1002/cbdv.200490168

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