Germanium Plasmon Enhanced Resonators for Label-Free Terahertz Protein Sensing

Autor(en): Bettenhausen, Maximilian
Roemer, Friedhard
Witzigmann, Bernd
Flesch, Julia
Kurre, Rainer 
Korneev, Sergej
Piehler, Jacob 
You, Changjiang 
Kazmierczak, Marcin
Guha, Subhajit
Capellini, Giovanni
Schroeder, Thomas
Stichwörter: ABSORPTION-SPECTROSCOPY; BIOSENSOR; DIFFERENCE SPECTROSCOPY; DYNAMICS; Engineering; Engineering, Electrical & Electronic; IMMOBILIZATION; MEMBRANE; MONOLAYERS; NANOPARTICLES; PASSIVATION; protein conformation; semiconductor plasmonics; SURFACE; terahertz sensor
Erscheinungsdatum: 2018
Herausgeber: WALTER DE GRUYTER GMBH
Journal: FREQUENZ
Volumen: 72
Ausgabe: 3-4, SI
Startseite: 113
Seitenende: 122
Zusammenfassung: 
A Terahertz protein sensing concept based on subwavelength Ge resonators is presented. Ge bowtie resonators, compatible with CMOS fabrication technology, have been designed and characterized with a resonance frequency of 0.5 THz and calculated local intensity enhancement of 10.000. Selective biofunctionalization of Ge resonators on Si wafer was achieved in one step using lipoic acid-HaloTag ligand (LA-HTL) for biofunctionalization and passivation. The results lay the foundation for future investigation of protein tertiary structure and the dynamics of protein hydration shell in response to protein conformation changes.
ISSN: 00161136
DOI: 10.1515/freq-2018-0009

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