Germanium Plasmon Enhanced Resonators for Label-Free Terahertz Protein Sensing
| Autor(en): | Bettenhausen, Maximilian Roemer, Friedhard Witzigmann, Bernd Flesch, Julia Kurre, Rainer Korneev, Sergej Piehler, Jacob You, Changjiang Kazmierczak, Marcin Guha, Subhajit Capellini, Giovanni Schroeder, Thomas |
Stichwörter: | ABSORPTION-SPECTROSCOPY; BIOSENSOR; DIFFERENCE SPECTROSCOPY; DYNAMICS; Engineering; Engineering, Electrical & Electronic; IMMOBILIZATION; MEMBRANE; MONOLAYERS; NANOPARTICLES; PASSIVATION; protein conformation; semiconductor plasmonics; SURFACE; terahertz sensor | Erscheinungsdatum: | 2018 | Herausgeber: | WALTER DE GRUYTER GMBH | Journal: | FREQUENZ | Volumen: | 72 | Ausgabe: | 3-4, SI | Startseite: | 113 | Seitenende: | 122 | Zusammenfassung: | A Terahertz protein sensing concept based on subwavelength Ge resonators is presented. Ge bowtie resonators, compatible with CMOS fabrication technology, have been designed and characterized with a resonance frequency of 0.5 THz and calculated local intensity enhancement of 10.000. Selective biofunctionalization of Ge resonators on Si wafer was achieved in one step using lipoic acid-HaloTag ligand (LA-HTL) for biofunctionalization and passivation. The results lay the foundation for future investigation of protein tertiary structure and the dynamics of protein hydration shell in response to protein conformation changes. |
ISSN: | 00161136 | DOI: | 10.1515/freq-2018-0009 |
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