A Dead Gene Walking: Convergent Degeneration of a Clade of MADS-Box Genes in Crucifers
Autor(en): | Hoffmeier, Andrea Gramzow, Lydia Bhide, Amey S. Kottenhagen, Nina Greifenstein, Andreas Schubert, Olesia Mummenhoff, Klaus Becker, Annette Theissen, Guenter |
Stichwörter: | ARABIDOPSIS-THALIANA; B-sister genes; Biochemistry & Molecular Biology; Delayed Convergent Asymmetric Degeneration; dosage subfunctionalization; DUPLICATE GENES; Evolutionary Biology; FLOWER DEVELOPMENT; gene death; gene duplication; Genetics & Heredity; GENOME-WIDE IDENTIFICATION; MOLECULAR EVOLUTION; MULTIPLE ALIGNMENT; PHYLOGENETIC ANALYSIS; PLANT DEVELOPMENT; PROTEIN INTERACTIONS; TRANSCRIPTION FACTORS | Erscheinungsdatum: | 2018 | Herausgeber: | OXFORD UNIV PRESS | Journal: | MOLECULAR BIOLOGY AND EVOLUTION | Volumen: | 35 | Ausgabe: | 11 | Startseite: | 2618 | Seitenende: | 2638 | Zusammenfassung: | Genes are ``born,'' and eventually they ``die.'' These processes shape the phenotypic evolution of organisms and are hence of great biological interest. If genes die in plants, they generally do so quite rapidly. Here, we describe the fate of GOA-like genes that evolve in a dramatically different manner. GOA-like genes belong to the subfamily of B-sister genes of MIKC-type MADS-box genes. Typical MIKC-type genes encode conserved transcription factors controlling plant development. We show that ABS-like genes, a Glade of B-sister genes, are indeed highly conserved in crucifers (Brassicaceae) maintaining the ancestral function of B-sister genes in ovule and seed development. In contrast, their closest paralogs, the GOA-like genes, have been undergoing convergent gene death in Brassicaceae. Intriguingly, erosion of GOA-like genes occurred after millions of years of coexistence with ABS-like genes. We thus describe Delayed Convergent Asymmetric Degeneration, a so far neglected but possibly frequent pattern of duplicate gene evolution that does not fit classical scenarios. Delayed Convergent Asymmetric Degeneration of GOA-like genes may have been initiated by a reduction in the expression of an ancestral GOA-like gene in the stem group of Brassicaceae and driven by dosage subfunctionalization. Our findings have profound implications for gene annotations in genomics, interpreting patterns of gene evolution and using genes in phylogeny reconstructions of species. |
ISSN: | 07374038 | DOI: | 10.1093/molbev/msy142 |
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