Synthesis of new paramagnetic fatty acids and lipophilic spin labels
| Autor(en): | Balog, Maria Abe, Christoph Kalai, Tamas Steinhoff, Heinz-Juergen Jeko, Jozsef Hideg, Kalman |
Stichwörter: | Chemistry; Chemistry, Organic; CROSS-COUPLING REACTIONS; DERIVATIVES; EPR; fatty acids; free radicals; Grignard reaction; lipids; MITOCHONDRIA; NITROXYLS; palladium-catalyzed reactions; PEROXIDE; PHOSPHOLIPID-BILAYERS; RADICALS; SPECTROSCOPY; VERSATILE | Erscheinungsdatum: | 2007 | Herausgeber: | GEORG THIEME VERLAG KG | Journal: | SYNTHESIS-STUTTGART | Ausgabe: | 11 | Startseite: | 1663 | Seitenende: | 1670 | Zusammenfassung: | Starting from readily available five-membered cyclic nitrones, paramagnetic analogues of palmitic and hexadec-2E-enoic acids are described with a range of pyrrolidine ring orientations. Herein we report the synthesis of 3,4-disubstituted lipophilic pyrroline nitroxides through a palladium-catalyzed cross-coupling reaction. Lipophilic phosphonium salt and SH-specific labels (methanethiosulfonates and isoselenuronium salts) with allylic and propargylic terminal groups are also described. |
ISSN: | 00397881 | DOI: | 10.1055/s-2007-966067 |
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