Biofilm formation by Salmonella enterica serovar Typhimurium colonizing solid tumours

Autor(en): Crull, Katja
Rohde, Manfred
Westphal, Kathrin
Loessner, Holger
Wolf, Kathrin
Felipe-Lopez, Alfonso
Hensel, Michael 
Weiss, Siegfried
Stichwörter: BACTERIA; Cell Biology; CELLULOSE; CURLI; ESCHERICHIA-COLI; GENE-EXPRESSION; Microbiology; MULTICELLULAR BEHAVIOR; SPP.; THIN AGGREGATIVE FIMBRIAE
Erscheinungsdatum: 2011
Herausgeber: WILEY
Journal: CELLULAR MICROBIOLOGY
Volumen: 13
Ausgabe: 8
Startseite: 1223
Seitenende: 1233
Zusammenfassung: 
Systemic administration of Salmonella enterica serovar Typhimurium to tumour bearing mice results in preferential colonization of the tumours and retardation of tumour growth. Although the bacteria are able to invade the tumour cells in vitro, in tumours they were never detected intracellularly. Ultrastructural analysis of Salmonella-colonized tumours revealed that the bacteria had formed biofilms. Interestingly, depletion of neutrophilic granulocytes drastically reduced biofilm formation. Obviously, bacteria form biofilms in response to the immune reactions of the host. Importantly, we tested Salmonella mutants that were no longer able to form biofilms by deleting central regulators of biofilm formation. Such bacteria could be observed intracellularly in immune cells of the host or in tumour cells. Thus, tumour colonizing S. typhimurium might form biofilms as protection against phagocytosis. Since other bacteria are behaving similarly, solid murine tumours might represent a unique model to study biofilm formation in vivo.
ISSN: 14625814
DOI: 10.1111/j.1462-5822.2011.01612.x

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