A 2'->5'-adenylate trimer with a positively charged 2'(3')-terminal 8-(4-aminobutyl)aminoadenosine residue: Synthesis, conformation and RNase L binding
| Autor(en): | Mikhailopulo, IA Kalinichenko, EN Podkopaeva, TL Kelve, M Saarma, M Lidaks, MY Rosemeyer, H Seela, F |
Stichwörter: | 2-5A; ACID; ANALOGS; ANTI CONFORMATION; Biochemistry & Molecular Biology; BOND; FRAGMENTS; NMR; NUCLEAR MAGNETIC-RESONANCE; NUCLEOTIDES; PURINE NUCLEOSIDES | Erscheinungsdatum: | 1997 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 16 | Ausgabe: | 10-11 | Startseite: | 1855 | Seitenende: | 1873 | Zusammenfassung: | An analogue of the 2-5A core trimer containing an 8-(4-aminobutyl)-aminoadenosine (1, A*) residue at the 2'(3')-terminus [2; (2',5')A(2)A*] was synthesized. The conformation of (2',5')A(2)A* was studied by H-1, C-13-NMR, and CD spectroscopy. The (2',5')A(2)A* exhibits very low binding ability to the RNase L of mouse L cells, but slightly enhanced resistance to digestion by SVPD compared to the parent trimer. |
ISSN: | 15257770 | DOI: | 10.1080/07328319708002539 |
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