Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy
| Autor(en): | Espinoza, Sara Mueller, Matthias Jenneboer, Heike Peulen, Lukas Bradley, Tiara Purschke, Martin Haase, Markus Rahmanzadeh, Ramtin Juestel, Thomas |
Stichwörter: | A549 CELLS; BIOLOGY; CARCINOMA; Chemistry; Chemistry, Physical; energy transfer; INDUCED DNA-DAMAGE; LUMINESCENCE PROPERTIES; LUPO4; Materials Science; Materials Science, Multidisciplinary; NANOPARTICLES; Nanoscience & Nanotechnology; Nd3+ photoluminescence; Pr3+ photoluminescence; radiation therapy; RADIOSENSITIZER; RADIOTHERAPY; Science & Technology - Other Topics; SCINTILLATION PROPERTIES; UV nanoscale scintillators; X-rays | Erscheinungsdatum: | 2019 | Herausgeber: | WILEY-V C H VERLAG GMBH | Journal: | PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION | Volumen: | 36 | Ausgabe: | 10 | Zusammenfassung: | UV-C emitting nanoscale scintillators can be used to sensitize cancer cells selectively against X-rays during radiation therapy, due to the lethal DNA lesions caused by UV-C photons. Unfortunately, nanoscale particles (NPs) show decreased UV-C emission intensity. In this paper, the influence of different Nd3+ concentrations on the UV-C emission of micro- and nanoscale LuPO4:Pr3+ is investigated upon X-ray irradiation and vacuum UV excitation (160 nm). Co-doped LuPO4 results in increased UV-C emission independent of excitation source due to energy transfer from Nd3+ to Pr3+. The highest UV-C emission intensity is observed for LuPO4:Pr3+,Nd3+(1%,2.5%) upon X-ray irradiation. Finally, LuPO4 NPs co-doped with different dopant concentrations are synthesized, and the biological efficacy of the combined approach (X-rays and UV-C) is assessed using the colony formation assay. Cell culture experiments confirm increased cell death compared to X-rays alone due to the formation of UV-specific DNA damages, supporting the feasibility of this approach. |
ISSN: | 09340866 | DOI: | 10.1002/ppsc.201900280 |
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