Higher order spike synchrony in prefrontal cortex during visual memory

Autor(en): Pipa, G. 
Munk, M.H.J.
Stichwörter: Behavioral performance; Joint-spike events; Joint-spike patterns; Medical computing; Multi-unit activity; Neurology, Behavioral performance; prefrontal cortex; Primate prefrontal cortex; Short term memory; spike; Spike patterns; Spike synchrony; stimulus; Stimulus coding; Stimulus coding, Neurons, modulation; visual memory; Visual short-term memory
Erscheinungsdatum: 2011
Herausgeber: Frontiers Research Foundation
Journal: Frontiers in Computational Neuroscience
Volumen: 5
Zusammenfassung: 
Precise temporal synchrony of spike firing has been postulated as an important neuronal mechanism for signal integration and the induction of plasticity in neocortex. As prefrontal cortex plays an important role in organizing memory and executive functions, the convergence of multiple visual pathways onto PFC predicts that neurons should preferentially synchronize their spiking when stimulus information is processed. Furthermore, synchronous spike firing should intensify if memory processes require the induction of neuronal plasticity, even if this is only for short-term. Here we show with multiple simultaneously recorded units in ventral prefrontal cortex that neurons participate in 3 ms precise synchronous discharges distributed across multiple sites separated by at least 500 μm. The frequency of synchronous firing is modulated by behavioral performance and is specific for the memorized visual stimuli. In particular, during the memory period in which activity is not stimulus driven, larger groups of up to seven sites exhibit performance dependent modulation of their spike synchronization. © 2011 Pipa and Munk.
ISSN: 16625188
DOI: 10.3389/fncom.2011.00023
Externe URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84555203568&doi=10.3389%2ffncom.2011.00023&partnerID=40&md5=7e39c8059d09c6ee07b61a0bf4c3d80a

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