7-deaza-2 `-deoxy-7-propynylguanosine

Autor(en): Seela, F
Shaikh, K
Eickmeier, H
Stichwörter: 2'-DEOXYGUANOSINE; 7-DEAZA-2'-DEOXYGUANOSINE; Chemistry; Chemistry, Multidisciplinary; CRYSTAL; Crystallography; DNA; NUCLEIC-ACIDS; NUCLEOSIDES; OLIGODEOXYNUCLEOTIDES; OLIGONUCLEOTIDES; PROPYNE ANALOGS; RECOGNITION
Erscheinungsdatum: 2004
Herausgeber: BLACKWELL MUNKSGAARD
Journal: ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
Volumen: 60
Ausgabe: 7
Startseite: O489-O491
Zusammenfassung: 
The title compound, C14H16N4O4, adopts the anti conformation at the glycosylic bond [chi = 117.1 (5)degrees]. The sugar pucker of the 2'-deoxyribofuranosyl moiety is C2'-endo-C3'-exo, T-2(3) (S-type). The orientation of the exocyclic C4'-C5' bond is sc (gauche). The propynyl group is linear and coplanar with the nucleobase moiety. The structure of the compound is stabilized by several hydrogen bonds (N - H ... O and O - H ... O), leading to the formation of a multi-layered network. The nucleobases, as well as the propynyl groups, are stacked. This stacking might cause the extraordinary stability of DNA duplexes containing this compound.
ISSN: 01082701
DOI: 10.1107/S0108270104011552

Show full item record

Page view(s)

1
Last Week
0
Last month
0
checked on Mar 1, 2024

Google ScholarTM

Check

Altmetric