Xylose-DNA containing the four natural bases
Autor(en): | Seela, F Heckel, M Rosemeyer, H |
Stichwörter: | ACID RELATED-COMPOUNDS; BACKBONE; BUILDING-BLOCKS; Chemistry; Chemistry, Multidisciplinary; NUCLEOSIDES; SOLID-PHASE SYNTHESIS; STABILITY | Erscheinungsdatum: | 1996 | Herausgeber: | NEW SWISS CHEMICAL SOC | Journal: | HELVETICA CHIMICA ACTA | Volumen: | 79 | Ausgabe: | 5 | Startseite: | 1451 | Seitenende: | 1461 | Zusammenfassung: | Oligonucleotides containing (2'-deoxy-beta-D-xylofuranosyl)guanine have been prepared. For this purpose 2-aminoadenosine (5) was synthesized and converted to 2'-deoxy-beta-D-xyloguanosine (1). The related 2'-deoxy-beta-D-xyloisoguanosine (3) and 2'-deoxy-beta-D-xyloxanthosine (4) were also synthesized. Compound 1 was converted to the phosphonate and phosphoramidite building blocks 10 and 11, respectively. The oligodeoxynucleotide (5'-3')d(xG-xT-xA-xG-xA-xA-xT-xT-xC-xT-xA-xC-T) (18) formed a duplex with the same T-m as the parent (5'-3')-(G-T-A-G-A-A-T-T-C-T-A-C) (19), but with an inverted CD spectrum. |
ISSN: | 0018019X | DOI: | 10.1002/hlca.19960790518 |
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geprüft am 17.05.2024