7-deaza-2 `-deoxyguanosines functionalized with 7-(omega-aminoalk-1-ynyl) residues

Autor(en): Ramzaeva, N
Mittelbach, C
Seela, F
Stichwörter: Biochemistry & Molecular Biology; OLIGONUCLEOTIDES
Erscheinungsdatum: 1999
Herausgeber: MARCEL DEKKER INC
Journal: NUCLEOSIDES & NUCLEOTIDES
Volumen: 18
Ausgabe: 6-7
Startseite: 1439
Seitenende: 1440
Zusammenfassung: 
The Pd(0)-catalyzed cross coupling reaction of 7-iodo-7-deaza-2'-deoxyguanosine (1, I(7)c(7)G(d)) With the phthalimido-protected omega-aminoalkines 2a-c gave the compounds 3a-c. They were converted into the phosphoramidite building block 4a-c as well as the phosphonates 5a-c. Compounds 4a and 4c were incorporated into oligodeoxynucleotides of different sequence and their duplex stabilities were measured and compared with those of the unmodified counterparts.
Beschreibung: 
XIII International Round Table Conference on Nucleosides, Nucleotides and their Biological Applications, MONTPELLIER, FRANCE, SEP 06-10, 1998
ISSN: 07328311
DOI: 10.1080/07328319908044747

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