N-8-(2 `-O-methylribofuranosyl)-8-aza-7-deazaadenine monohydrate

Autor(en): Zhang, XM
Budow, S
Leonard, P
Eickmeier, H
Seela, F
Stichwörter: 8-AZA-7-DEAZAADENINE; BASE-PAIRING PROPERTIES; Chemistry; Chemistry, Multidisciplinary; CRYSTAL; Crystallography; DERIVATIVES; DNA BACKBONE
Erscheinungsdatum: 2006
Herausgeber: INT UNION CRYSTALLOGRAPHY
Journal: ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
Volumen: 62
Ausgabe: 2
Startseite: O79-O81
Zusammenfassung: 
In the title compound, 4-amino-2-(2-O-methyl-beta-D-ribofuranosyl)-2H- pyrazolo[3,4-d] pyrimidine monohydrate, C11H15N5O4 center dot H2O, the conformation of the N-glycosylic bond is syn [chi = 20.1 (2) degrees]. The ribofuranose moiety shows a C3'-endo (T-3(2)) sugar puckering (N-type sugar), and the conformation at the exocyclic C4' - C5' bond is -ap ( trans). The nucleobases are stacked head-to-head. The three-dimensional packing of the crystal structure is stabilized by hydrogen bonds between the 2'-O-methylribonucleosides and the solvent molecules.
ISSN: 20532296
DOI: 10.1107/S0108270105041983

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