N-8-(2 `-O-methylribofuranosyl)-8-aza-7-deazaadenine monohydrate
Autor(en): | Zhang, XM Budow, S Leonard, P Eickmeier, H Seela, F |
Stichwörter: | 8-AZA-7-DEAZAADENINE; BASE-PAIRING PROPERTIES; Chemistry; Chemistry, Multidisciplinary; CRYSTAL; Crystallography; DERIVATIVES; DNA BACKBONE | Erscheinungsdatum: | 2006 | Herausgeber: | INT UNION CRYSTALLOGRAPHY | Journal: | ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | Volumen: | 62 | Ausgabe: | 2 | Startseite: | O79-O81 | Zusammenfassung: | In the title compound, 4-amino-2-(2-O-methyl-beta-D-ribofuranosyl)-2H- pyrazolo[3,4-d] pyrimidine monohydrate, C11H15N5O4 center dot H2O, the conformation of the N-glycosylic bond is syn [chi = 20.1 (2) degrees]. The ribofuranose moiety shows a C3'-endo (T-3(2)) sugar puckering (N-type sugar), and the conformation at the exocyclic C4' - C5' bond is -ap ( trans). The nucleobases are stacked head-to-head. The three-dimensional packing of the crystal structure is stabilized by hydrogen bonds between the 2'-O-methylribonucleosides and the solvent molecules. |
ISSN: | 20532296 | DOI: | 10.1107/S0108270105041983 |
Show full item record