Acetaminophen use: A risk for asthma?
Autor(en): | Allmers, Henning Skudlik, Christoph John, Swen Malte |
Stichwörter: | ADULTS; Allergy; ASSOCIATION; CHILDHOOD; DISEASE; GLUTATHIONE LEVELS; Immunology; LUNG; PARACETAMOL USE | Erscheinungsdatum: | 2009 | Herausgeber: | CURRENT MEDICINE GROUP | Journal: | CURRENT ALLERGY AND ASTHMA REPORTS | Volumen: | 9 | Ausgabe: | 2 | Startseite: | 164 | Seitenende: | 167 | Zusammenfassung: | A growing number of studies show that regular use of acetaminophen (paracetamol) carries a dose-dependent risk of developing allergies in general and asthma in particular and of worsening other respiratory diseases and lung function. The most disturbing finding has come from the population-based Avon Longitudinal Study of Parents and Children, in which use of paracetamol-but not aspirin-in late pregnancy was positively associated with asthma when comparing children whose mothers took paracetamol ``sometimes'' and ``most days/daily'' with those whose mothers never took it. Assuming a causal relationship, the percentage of asthma attributable to paracetamol use in late pregnancy was 7%. In this review, we present data from the most important studies published since 2000. Although the pathophysiology remains unclear, the available data justify a warning to the general public that the uncritical use of over-the-counter acetaminophen can lead to the development of allergies and asthma, even in utero. |
ISSN: | 15297322 | DOI: | 10.1007/s11882-009-0024-3 |
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geprüft am 12.05.2024