1-DEAZA-2'-DEOXYADENOSINE - PHOSPHONATE AND PHOSPHORAMIDITE BUILDING-BLOCKS FOR SOLID-PHASE OLIGONUCLEOTIDE SYNTHESIS
Autor(en): | SEELA, F WENZEL, T |
Stichwörter: | Chemistry; Chemistry, Organic; DEOXYNUCLEOSIDES; DNA; RIBONUCLEOSIDES | Erscheinungsdatum: | 1993 | Herausgeber: | PERGAMON-ELSEVIER SCIENCE LTD | Journal: | HETEROCYCLES | Volumen: | 36 | Ausgabe: | 2 | Startseite: | 237 | Seitenende: | 242 | Zusammenfassung: | The synthesis of the 3'-[(2-cyanoethyl)diisopropylphosphoramidite] (3b) and the 3'-phosphonate (3a) of 1-deaza-2'-deoxyadenosine (1b) is described. For this purpose compound lb was protected at the 6-amino group with a benzoyl residue. Ensuing 4,4'-dimethoxytritylation of lb and phosphitylation afforded the P(III) derivatives(3a) and (3b). They were successfully employed in solid-phase oligodeoxyribonucleotide synthesis of d(c1A-c1A-c1A-A-A-A) (6). C-13-Nmr and N-15-nmr spectra of the compounds (1-5) are discussed. |
ISSN: | 03855414 | DOI: | 10.3987/COM-92-6214 |
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geprüft am 05.05.2024