Modified purine nucleosides as dangling ends of DNA duplexes: the effect of the nucleobase polarizability on stacking interactions

Autor(en): Rosemeyer, H 
Seela, F
Stichwörter: ACID; AFFINITY; AROMATIC STACKING; BASE-PAIRS; Chemistry; Chemistry, Organic; Chemistry, Physical; HELICES; OLIGODEOXYNUCLEOTIDES; OLIGONUCLEOTIDES; PYRIMIDINES; RESIDUES; STABILITY
Erscheinungsdatum: 2002
Herausgeber: ROYAL SOC CHEMISTRY
Journal: JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
Ausgabe: 4
Startseite: 746
Seitenende: 750
Zusammenfassung: 
Base-modified nucleotide residues have been appended to the 5'-terminus of the self-complementary oligo-2'-deoxynucleotide duplex [5'-d(CGCGCG)](2) as dangling ends. Temperature-dependent UV measurements on the resulting oligomers indicate generally higher thermal stabilities (T-m) compared to that without an overhanging end. The duplex stabilization (DeltaT(m)) was correlated with the molecular polarizability (a(m)) of the base of the pendant nucleoside showing that: the higher the molecular polarizability a(m) of a dangling nucleobase, the higher the thermal stability of the DNA duplex.
ISSN: 1472779X
DOI: 10.1039/b200077f

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