3-DEAZAPURINES AND 7-DEAZAPURINES - DUPLEX STABILITY OF OLIGONUCLEOTIDES CONTAINING MODIFIED ADENINE OR GUANINE BASES
| Autor(en): | GREIN, T LAMPE, S MERSMANN, K ROSEMEYER, H THOMAS, H SEELA, F |
Stichwörter: | 3-DEAZA-2'-DEOXYADENOSINE; 7-DEAZA-2'-DEOXYADENOSINE; 7-DEAZA-2'-DEOXYGUANOSINE; B-DNA; Chemistry; Chemistry, Medicinal; Chemistry, Organic; OLIGODEOXYRIBONUCLEOTIDES; Pharmacology & Pharmacy; POLYNUCLEOTIDES; RECOGNITION; REPLACING DA; SOLID-PHASE SYNTHESIS; TRACTS | Erscheinungsdatum: | 1994 | Herausgeber: | PERGAMON-ELSEVIER SCIENCE LTD | Journal: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | Volumen: | 4 | Ausgabe: | 8 | Startseite: | 971 | Seitenende: | 976 | Zusammenfassung: | Oligonucleotide duplexes were destabilized when the purine bases of 2'-deoxyadenosine or 2'-deoxyguanosine were replaced by the corresponding 3-deazapurine (imidazo[4,5-c]pyridine) or 7-deazapurine (pyrrolo[2,3-d]pyrimidine) derivatives. Only d(AT)(6) was stabilized by incorporation of c A when high salt condition were used. The stability of deazapurine base-protecting groups was also investigated. |
ISSN: | 0960894X | DOI: | 10.1016/S0960-894X(01)80665-X |
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geprüft am 17.05.2024
