2'-DEOXY-BETA-D-XYLOTHYMIDINYL-(3', 5')-2'-DEOXY-BETA-D-XYLOTHYMIDYLATE - STEREOCHEMICAL COURSE OF DINUCLEOSIDE PHOSPHONATE FORMATION AND CONFORMATIONAL PROPERTIES

Autor(en): ROSEMEYER, H 
STRODTHOLZ, I
SEELA, F
Stichwörter: Chemistry; Chemistry, Medicinal; Chemistry, Organic; Pharmacology & Pharmacy; PHOSPHATES
Erscheinungsdatum: 1992
Herausgeber: PERGAMON-ELSEVIER SCIENCE LTD
Journal: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volumen: 2
Ausgabe: 10
Startseite: 1201
Seitenende: 1206
Zusammenfassung: 
Coupling of 5'-DMT-protected 1-(2-deoxy-beta-D-xylofuranosyl)thymine 3'-phosphonate with 3'-benzoylated 1-(2-deoxy-beta-D-xylofuranosyl)thymine gave the diastereoisomeric dinucleoside phosphonates 4/5 with the S(P) compound in preponderance (de, 29 %). Oxidation of 4/5 (I2, H2O) and removal of the protecting groups gave d(xTpxT) which exhibits an inverted CD-spectrum compared to d(TpT) but identical stacking interactions.
ISSN: 0960894X
DOI: 10.1016/S0960-894X(00)80214-0

Show full item record

Page view(s)

1
Last Week
0
Last month
0
checked on Feb 23, 2024

Google ScholarTM

Check

Altmetric