Mechanochemical Ni-Catalysed Arylation of Ortho-Hydroxyarylenaminones: Synthesis of Isoflavones
Autor(en): | Mkrtchyan, Satenik Jakubczyk, Michal Lanka, Suneel Yar, Muhammad Mahmood, Tariq Ayub, Khurshid Sillanpaa, Mika Thomas, Christine M. Iaroshenko, Viktor O. |
Stichwörter: | ANALOGS; Arylation; ARYLBORONIC ACIDS; CASCADES; Catalysis; Chemistry; Chemistry, Applied; Chemistry, Organic; CROSS-COUPLING REACTION; DERIVATIVES; H BOND TRIFLUOROMETHYLATION; Isoflavones; Mechanochemistry; Methodology; PROPARGYLIC ALCOHOLS; STRATEGY; WATER | Erscheinungsdatum: | 2022 | Herausgeber: | WILEY-V C H VERLAG GMBH | Journal: | ADVANCED SYNTHESIS & CATALYSIS | Volumen: | 364 | Ausgabe: | 20 | Startseite: | 3512 | Seitenende: | 3521 | Zusammenfassung: | This work describes two new synthetic methods for the preparation of isoflavones following the Ni-catalysed domino arylation reactions of the vast range of ortho-hydroxyarylenaminones utilising aromatic bromides as well as carboxylic acids. The presented protocols tolerated significant variation of all coupling partners and enabled synthesis of isoflavone library of twenty-three representatives. This is the first communicated precedent where the mechanic energy was utilised in the synthesis of isoflavones following the domino cyclisation mode. |
ISSN: | 1615-4150 | DOI: | 10.1002/adsc.202200645 |
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