7-deaza-2 `-deoxyxanthosine: Nucleobase protection and base pairing of oligonucleotides

Autor(en): Shaikh, Khalil I.
Leonard, Peter
Seela, Frank
Stichwörter: 2'-deoxyxanthosine; 7-deaza-2'-deoxyxanthosine; base pairing; Biochemistry & Molecular Biology; duplexes; GUANINE; NUCLEIC-ACIDS; NUCLEOTIDES; oligonucleotides; phosphoramidites; protecting groups; XANTHINE
Erscheinungsdatum: 2007
Herausgeber: TAYLOR & FRANCIS INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 26
Ausgabe: 6-7
Startseite: 737
Seitenende: 741
Zusammenfassung: 
Oligonucleolides containing 7-deaza-2'-deoxyxanthosine (1) and 2'-deoxyxanthosine (2) were prepared. The 2-(4-nitrophenyl)ethyl group is applicable for 7-deazaxanthine protection that is removed with DBU by beta-elimination, while the deprotection of the allyl residue with Pd (0) catalyst failed. Contrarily, the allyl group was found to be an excellent Protecting group for 2'-deoxyxanthosine (2). The base pairing of nucleosides 1 and 2 with the four canonical DNA canstituents as well as with 3 within the 12-mer duplexes is studied.
Beschreibung: 
Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006
ISSN: 15257770
DOI: 10.1080/15257770701490837

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