7-deaza-2 `-deoxyxanthosine: Nucleobase protection and base pairing of oligonucleotides
| Autor(en): | Shaikh, Khalil I. Leonard, Peter Seela, Frank |
Stichwörter: | 2'-deoxyxanthosine; 7-deaza-2'-deoxyxanthosine; base pairing; Biochemistry & Molecular Biology; duplexes; GUANINE; NUCLEIC-ACIDS; NUCLEOTIDES; oligonucleotides; phosphoramidites; protecting groups; XANTHINE | Erscheinungsdatum: | 2007 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 26 | Ausgabe: | 6-7 | Startseite: | 737 | Seitenende: | 741 | Zusammenfassung: | Oligonucleolides containing 7-deaza-2'-deoxyxanthosine (1) and 2'-deoxyxanthosine (2) were prepared. The 2-(4-nitrophenyl)ethyl group is applicable for 7-deazaxanthine protection that is removed with DBU by beta-elimination, while the deprotection of the allyl residue with Pd (0) catalyst failed. Contrarily, the allyl group was found to be an excellent Protecting group for 2'-deoxyxanthosine (2). The base pairing of nucleosides 1 and 2 with the four canonical DNA canstituents as well as with 3 within the 12-mer duplexes is studied. |
Beschreibung: | Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006 |
ISSN: | 15257770 | DOI: | 10.1080/15257770701490837 |
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