A Series of Non-Oxido Vi Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity

Autor(en): Banerjee, Atanu
Patra, Sushree Aradhana
Sahu, Gurunath
Sciortino, Giuseppe
Pisanu, Federico
Garribba, Eugenio
Carvalho, M. Fernanda N. N.
Correia, Isabel
Pessoa, Joao Costa
Reuter, Hans 
Dinda, Rupam
Stichwörter: (VO)-O-IV COMPLEXES; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; CELLULAR UPTAKE; Chemistry; Chemistry, Inorganic & Nuclear; CRYSTAL-STRUCTURE; DIOXIDOVANADIUM(V) COMPLEXES; OXIDOVANADIUM(V) COMPLEXES; OXOVANADIUM(V) COMPLEXES; SERUM-ALBUMIN; VANADIUM(IV) COMPLEXES
Erscheinungsdatum: 2023
Herausgeber: AMER CHEMICAL SOC
Journal: INORGANIC CHEMISTRY
Volumen: 62
Ausgabe: 20
Startseite: 7932
Seitenende: 7953
Zusammenfassung: 
A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4 , are reported. All the synthesized non-oxido VIV compounds are characterized by elemental analysis, spectroscopy (IR, UV-vis, and EPR), ESI-MS, as well as electrochemical techniques (cyclic voltammetry). Single-crystal X-ray diffraction studies of 1-3 reveal that the mononuclear non-oxido VIV complexes show distorted octahedral (1 and 2) or trigonal prismatic (3) arrangement around the non-oxido VIV center. EPR and DFT data indicate the coexistence of mer and fac isomers in solution, and ESI-MS results suggest a partial oxidation of [VIV(L1-4)2] to [VV(L1-4)2]+ and [VVO2(L1-4)]-; therefore, all these three complexes are plausible active species. Complexes 1-4 interact with bovine serum albumin (BSA) with a moderate binding affinity, and docking calculations reveal non-covalent interactions with different regions of BSA, particularly with Tyr, Lys, Arg, and Thr residues. In vitro cytotoxic activity of all complexes is assayed against the HT-29 (colon cancer) and HeLa (cervical cancer) cells and compared with the NIH-3T3 (mouse embryonic fibroblast) normal cell line by MTT assay and DAPI staining. The results suggest that complexes 1-4 are cytotoxic in nature and induce cell death in the cancer cell lines by apoptosis and that a mixture of VIV, VV, and VVO2 species could be responsible for the biological activity.
ISSN: 0020-1669
DOI: 10.1021/acs.inorgchem.3c00753

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