Pyrrolo[2,3-d]pyrimidine nucleosides: Synthesis and antitumor activity of 7-substituted 7-deaza-2 `-deoxyadenosines

Autor(en): Seela, F
Zulauf, M
Chen, SF
Stichwörter: ANTIVIRAL ACTIVITY; Biochemistry & Molecular Biology; BIS-NAPHTHALIMIDE; DERIVATIVES; DNA; NUCLEOTIDES; OLIGODEOXYNUCLEOTIDES; OLIGONUCLEOTIDES; POTENT; PROPYNE ANALOGS; TOYOCAMYCIN
Erscheinungsdatum: 2000
Herausgeber: MARCEL DEKKER INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 19
Ausgabe: 1-2
Startseite: 237
Seitenende: 251
Zusammenfassung: 
A one step synthesis, using the nucleoside 7-iodo-2'-deoxytubercidin (2b) in a Pd(0)/Cu(I)-catalyzed cross coupling reaction furnished a series of 7-alkynyl-2'-deoxytubercidin derivatives. The 7-iodo-, 7-chloro- or 7-bromo 2'-deoxytubercidins 2b-d as well as certain 7-alkynyl derivatives show significant activity against several tumor cell lines, with 7-iodo-2'-deoxytubercidin (2b) as the most effective compound.
ISSN: 15257770
DOI: 10.1080/15257770008033006

Show full item record

Page view(s)

1
Last Week
0
Last month
0
checked on Feb 26, 2024

Google ScholarTM

Check

Altmetric