Pyrrolo[2,3-d]pyrimidine nucleosides: Synthesis and antitumor activity of 7-substituted 7-deaza-2 `-deoxyadenosines
| Autor(en): | Seela, F Zulauf, M Chen, SF |
Stichwörter: | ANTIVIRAL ACTIVITY; Biochemistry & Molecular Biology; BIS-NAPHTHALIMIDE; DERIVATIVES; DNA; NUCLEOTIDES; OLIGODEOXYNUCLEOTIDES; OLIGONUCLEOTIDES; POTENT; PROPYNE ANALOGS; TOYOCAMYCIN | Erscheinungsdatum: | 2000 | Herausgeber: | MARCEL DEKKER INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 19 | Ausgabe: | 1-2 | Startseite: | 237 | Seitenende: | 251 | Zusammenfassung: | A one step synthesis, using the nucleoside 7-iodo-2'-deoxytubercidin (2b) in a Pd(0)/Cu(I)-catalyzed cross coupling reaction furnished a series of 7-alkynyl-2'-deoxytubercidin derivatives. The 7-iodo-, 7-chloro- or 7-bromo 2'-deoxytubercidins 2b-d as well as certain 7-alkynyl derivatives show significant activity against several tumor cell lines, with 7-iodo-2'-deoxytubercidin (2b) as the most effective compound. |
ISSN: | 15257770 | DOI: | 10.1080/15257770008033006 |
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geprüft am 12.05.2024
