pH-dependent assembly of DNA-gold nanoparticles based on the i-motif
| Autor(en): | Seela, Frank Budow, Simone |
Stichwörter: | 5-propynyl-2'-deoxycytidine; Biochemistry & Molecular Biology; DNA; gold nanoparticles; i-motif; self-assembly | Erscheinungsdatum: | 2007 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 26 | Ausgabe: | 6-7 | Startseite: | 755 | Seitenende: | 759 | Zusammenfassung: | Oligonucleotides containing stretches of 2'-deoxycytidine residues were immobilized on 15 nm gold nanoparticles. Under acidic pH conditions a reversible supramolecular assembly is formed, induced by the formation of the tetrameric i-motif structure. The replacement of 2'-deoxycytidine by 5-propynyl-2'-deoxycytidine (dC*) leads to novel i-motif structures. Oligonucleotides incorporating multiple residues of dC* were immobilized on 15 nm gold nanoparticles and are able to aggregate into i-motif structures even at non-optimal pH values. |
Beschreibung: | Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006 |
ISSN: | 15257770 | DOI: | 10.1080/15257770701490803 |
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