pH-dependent assembly of DNA-gold nanoparticles based on the i-motif

Autor(en): Seela, Frank
Budow, Simone
Stichwörter: 5-propynyl-2'-deoxycytidine; Biochemistry & Molecular Biology; DNA; gold nanoparticles; i-motif; self-assembly
Erscheinungsdatum: 2007
Herausgeber: TAYLOR & FRANCIS INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 26
Ausgabe: 6-7
Startseite: 755
Seitenende: 759
Zusammenfassung: 
Oligonucleotides containing stretches of 2'-deoxycytidine residues were immobilized on 15 nm gold nanoparticles. Under acidic pH conditions a reversible supramolecular assembly is formed, induced by the formation of the tetrameric i-motif structure. The replacement of 2'-deoxycytidine by 5-propynyl-2'-deoxycytidine (dC*) leads to novel i-motif structures. Oligonucleotides incorporating multiple residues of dC* were immobilized on 15 nm gold nanoparticles and are able to aggregate into i-motif structures even at non-optimal pH values.
Beschreibung: 
Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006
ISSN: 15257770
DOI: 10.1080/15257770701490803

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