Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity
Autor(en): | Wang, J Verbeure, B Luyten, I Froeyen, M Hendrix, C Rosemeyer, H Seela, F Van Aerschot, A Herdewijn, P |
Stichwörter: | Biochemistry & Molecular Biology; OLIGONUCLEOTIDES | Erscheinungsdatum: | 2001 | Herausgeber: | MARCEL DEKKER INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 20 | Ausgabe: | 4-7 | Startseite: | 785 | Seitenende: | 788 | Zusammenfassung: | Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H, resulting in cleavage of the RNA strand. |
Beschreibung: | XIVth International Roundtable on Nucleosides, Nucleotides and their Biological Applications, SAN FRANCISCO, CALIFORNIA, SEP 10-14, 2000 |
ISSN: | 15257770 | DOI: | 10.1081/NCN-100002430 |
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geprüft am 17.05.2024