Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity

Autor(en): Wang, J
Verbeure, B
Luyten, I
Froeyen, M
Hendrix, C
Rosemeyer, H 
Seela, F
Van Aerschot, A
Herdewijn, P
Stichwörter: Biochemistry & Molecular Biology; OLIGONUCLEOTIDES
Erscheinungsdatum: 2001
Herausgeber: MARCEL DEKKER INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 20
Ausgabe: 4-7
Startseite: 785
Seitenende: 788
Zusammenfassung: 
Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H, resulting in cleavage of the RNA strand.
Beschreibung: 
XIVth International Roundtable on Nucleosides, Nucleotides and their Biological Applications, SAN FRANCISCO, CALIFORNIA, SEP 10-14, 2000
ISSN: 15257770
DOI: 10.1081/NCN-100002430

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