Vacuolar-type proton pumps in insect epithelia

Autor(en): Wieczorek, Helmut 
Beyenbach, Klaus W.
Huss, Markus 
Vitavska, Olga 
Stichwörter: Aedes aegypti; AEDES-AEGYPTI; ANIMAL PLASMA-MEMBRANE; Biology; BLOWFLY SALIVARY-GLANDS; Drosophila melanogaster; DROSOPHILA-MELANOGASTER; ELECTRON-MICROSCOPY; H+-ATPASE; H+-translocating vacuolar-type ATPase; insect epithelia; Life Sciences & Biomedicine - Other Topics; Manduca sexta; MOSQUITO MALPIGHIAN TUBULES; PROTEIN-KINASE-A; tobacco hornworm; TOBACCO HORNWORM MIDGUT; V-ATPase; V-ATPASE SUBUNIT
Erscheinungsdatum: 2009
Herausgeber: COMPANY OF BIOLOGISTS LTD
Journal: JOURNAL OF EXPERIMENTAL BIOLOGY
Volumen: 212
Ausgabe: 11
Startseite: 1611
Seitenende: 1619
Zusammenfassung: 
Active transepithelial cation transport in insects was initially discovered in Malpighian tubules, and was subsequently also found in other epithelia such as salivary glands, labial glands, midgut and sensory sensilla. Today it appears to be established that the cation pump is a two-component system of a H+-transporting V-ATPase and a cation/nH(+) antiporter. After tracing the discovery of the V-ATPase as the energizer of K+/nH(+) antiport in the larval midgut of the tobacco hornworm Manduca sexta we show that research on the tobacco hornworm V-ATPase delivered important findings that emerged to be of general significance for our knowledge of V-ATPases, which are ubiquitous and highly conserved proton pumps. We then discuss the V-ATPase in Malpighian tubules of the fruitfly Drosophila melanogaster where the potential of post-genomic biology has been impressively illustrated. Finally we review an integrated physiological approach in Malpighian tubules of the yellow fever mosquito Aedes aegypti which shows that the V-ATPase delivers the energy for both transcellular and paracellular ion transport.
ISSN: 00220949
DOI: 10.1242/jeb.030007

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