Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer

Autor(en): Srivastava, P.
El Asrar, R. Abou
Knies, C.
Abramov, M.
Froeyen, M.
Rozenski, J.
Rosemeyer, H. 
Herdewijn, P.
Stichwörter: ANALOGS; B-DNA DODECAMER; Chemistry; Chemistry, Organic; CRYSTAL-STRUCTURE; GLYCEROL-NUCLEOSIDE TRIPHOSPHATES; LIFE; ORIGIN; PNA; RNA; STABLE DUPLEX FORMATION
Erscheinungsdatum: 2015
Herausgeber: ROYAL SOC CHEMISTRY
Journal: ORGANIC & BIOMOLECULAR CHEMISTRY
Volumen: 13
Ausgabe: 35
Startseite: 9249
Seitenende: 9260
Zusammenfassung: 
The search for prebiotic, nucleic acid precursors is, at its best, a speculative undertaking. Given the complex structure of RNA, it is not very likely that RNA was the first information system in the universe and thus finding possible precursor/s i.e. pre-RNA remains an open challenge. We, in this paper, have tried to construct nucleic acid polymers with a simple acyclic, achiral backbone. Such a linear, achiral backbone may have been formed from simple monomers that may have existed in the ``prebiotic soup''. We have shown that such polymers are capable of identifying the complementary ``other self'' and thus forming a potential system for information storage and transmission. This study thus involves investigation of nucleic acid analogues with a modified backbone that are likely to have formed in the prebiotic setting.
ISSN: 14770520
DOI: 10.1039/c5ob00898k

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