Up against the Wall: Is Yeast Cell Wall Integrity Ensured by Mechanosensing in Plasma Membrane Microdomains?

Autor(en): Kock, Christian 
Dufrene, Yves F.
Heinisch, Juergen J.
Stichwörter: ANTIFUNGAL AGENTS; ATOMIC-FORCE MICROSCOPY; BAKERS-YEAST; Biotechnology & Applied Microbiology; KLUYVEROMYCES-LACTIS; Microbiology; O-MANNOSYLATION; PROTEIN-KINASE-C; SACCHAROMYCES-CEREVISIAE; SENSOR; STRESS-RESPONSE; WSC1
Erscheinungsdatum: 2015
Herausgeber: AMER SOC MICROBIOLOGY
Journal: APPLIED AND ENVIRONMENTAL MICROBIOLOGY
Volumen: 81
Ausgabe: 3
Startseite: 806
Seitenende: 811
Zusammenfassung: 
Yeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of antifungal drugs. A set of five membrane-spanning sensors (Wsc1 to Wsc3, Mid2, and Mtl1) detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. We here summarize the latest advances in the structure/function relationship primarily of the Wsc1 sensor and critically review the evidence that it acts as a mechanosensor. The relevance and physiological significance of the information obtained for the function of the other CWI sensors, as well as expected future developments, are discussed.
ISSN: 00992240
DOI: 10.1128/AEM.03273-14

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