Preoperative Interleukin-22 Values Add Valuable Information for Outcome Prediction Following Orthotopic Liver Transplantation: A Preliminary Study

Autor(en): Bingold, Tobias M.
Just, Lara
Cuca, Colleen
Zacharowski, Kai
Moench, Christian
Muehl, Heiko
Wissing, Heimo
Pipa, Gordon 
Rosenberger, Peter
Bechstein, Wolf O.
Paulus, Patrick
Scheller, Bertram
Stichwörter: CELLS; CIRRHOSIS; CYTOKINES; DISEASE; End Stage Liver Disease; HEPATOCELLULAR-CARCINOMA; Liver Transplantation; MELD; MODEL; Patient Outcome Assessment; SEVERITY; Surgery; SURVIVAL; Transplantation; UNITED-STATES
Erscheinungsdatum: 2014
Volumen: 19
Background: Recent findings support the idea that interleukin (IL)-22 serum levels are related to disease severity in end-stage liver disease. Existing scoring systems - Model for End-Stage Liver Disease (MELD), Survival Outcomes Following Liver Transplantation (SOFT) and Pre-allocation-SOFT (P-SOFT) - are well-established in appraising survival rates with or without liver transplantation. We tested the hypothesis that IL-22 serum levels at transplantation date correlate with survival and potentially have value as a predictive factor for survival. Material/Methods: MELD, SOFT, and P-SOFT scores were calculated to estimate post-transplantation survival. Serum levels of IL-22, IL-6, IL-10, C-reactive protein (CRP), and procalcitonin (PCT) were collected prior to transplantation in 41 patients. Outcomes were assessed at 3 months, 1 year, and 3 years after transplantation. Results: IL-22 significantly correlated with MELD, P-SOFT, and SOFT scores (Rs 0.35, 0.63, 0.56 respectively, p<0.05) and with the discrimination in post-transplantation survival. IL-6 showed a heterogeneous pattern (Rs 0.40, 0.63, 0.57, respectively, p<0.05); CRP and PCT did not correlate. We therefore added IL-22 serum values to existing scoring systems in a generalized linear model (GLM), resulting in a significantly improved outcome prediction in 58% of the cases for both the P-SOFT (p<0.01) and SOFT scores (p<0.001). Conclusions: Further studies are needed to address the concept that IL-22 serum values at the time of transplantation provide valuable information about survival rates following orthotopic liver transplantation.
ISSN: 14259524

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